منابع مشابه
Membrane biophysics
In physics, we usually want to reduce the behavior of the system to fit it to a formula. In biology, however, all the details of the system are important; their organization makes for life. Thus the organization of proteins in the plasma membrane is critical for various biological processes that occur on membranes. My purpose here is to introduce readers first to the opportunities for learning ...
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Förster resonance energy transfer (FRET), in most applications used as a "spectroscopic ruler," allows an easy determination of the donor-acceptor intermolecular distance. However, the situation becomes complex in membranes, since around each donor there is an ensemble of acceptors at non-correlated distances. In this review, state-of-the-art methodologies for this situation are presented, usua...
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α-Synuclein is an intrinsically disordered protein whose aggregation is a hallmark of Parkinson's disease. In neurons, α-synuclein is thought to play important roles in mediating both endo- and exocytosis of synaptic vesicles through interactions with either the lipid bilayer or other proteins. Upon membrane binding, the N-terminus of α-synuclein forms a helical structure and inserts into the h...
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We know an enormous amount about the chemistry of a living cell, but next to nothing about its physics — the interplay of forces between organelles and molecules that governs the cell’s detailed behaviour. Think of the plasma membrane, for example: an oily sea of phospholipid molecules studded with protein ‘icebergs’ of different shapes and sizes, some floating free and others anchored at their...
متن کاملRole of membrane biophysics in Alzheimer's–related cell pathways
Cellular membrane alterations are commonly observed in many diseases, including Alzheimer's disease (AD). Membrane biophysical properties, such as membrane molecular order, membrane fluidity, organization of lipid rafts, and adhesion between membrane and cytoskeleton, play an important role in various cellular activities and functions. While membrane biophysics impacts a broad range of cellular...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2006
ISSN: 0960-9822
DOI: 10.1016/j.cub.2006.03.050